Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | UGCG | Q16739 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7998697 | 0.85 | HTR1A (0.52) | HTR1AKDM4EMAPK1MAPTMEN1 | |
| SCHEMBL16596083 | 0.84 | GRIN2B (0.45) | MEN1KMT2AUGCGSLC6A4 | |
| SCHEMBL21122987 | 0.84 | GRIN2B (0.45) | MEN1KMT2AUGCGSLC6A4 | |
| SCHEMBL7995727 | 0.82 | ALDH1A1 (0.45) | HTR1AMEN1KMT2ALMNASLC6A4 | |
| SCHEMBL21729342 | 0.82 | SMN1; SMN2 (0.51) | HTR1AKDM4EMAPK1MAPTMEN1 | |
| SCHEMBL18069816 | 0.81 | GRIN2B (0.45) | MEN1KMT2AUGCGSLC6A4 | |
| SCHEMBL15133703 | 0.79 | PDE4D (0.53) | MAPK1MEN1KMT2ALMNAHTT | |
| SCHEMBL13108748 | 0.78 | KDM4E (0.59) | HTR1AKDM4EMAPK1MAPTMEN1 | |
| SCHEMBL25180903 | 0.77 | CYP3A4 (0.43) | MAPK1MEN1KMT2ALMNAHTT | |
| SCHEMBL13342872 | 0.77 | HTR1A (0.65) | HTR1AKDM4EMAPK1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3912977-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES | BioMarin Pharmaceutical Inc. (US) | 2021-11-24 | — | — | EP | disclosed |