Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24045407 | 0.85 | HTR1A (0.51) | HTR1AMAPK1KDM4EMAPTMEN1 | |
| SCHEMBL21729342 | 0.83 | SMN1; SMN2 (0.51) | HTR1AMAPK1KDM4EMAPTMEN1 | |
| SCHEMBL13108748 | 0.79 | KDM4E (0.59) | HTR1AMAPK1KDM4EMAPTMEN1 | |
| SCHEMBL13342872 | 0.79 | HTR1A (0.65) | HTR1AMAPK1KDM4EMAPTMEN1 | |
| SCHEMBL20382528 | 0.79 | HTR1A (0.65) | HTR1AMAPK1KDM4EMAPTMEN1 | |
| SCHEMBL8106834 | 0.79 | HTR1A (0.65) | HTR1AMAPK1KDM4EMAPTMEN1 | |
| SCHEMBL7995727 | 0.78 | ALDH1A1 (0.45) | HTR1AMEN1KMT2ASLC6A4SLC6A3 | |
| SCHEMBL23732090 | 0.75 | SLC6A2 (0.45) | HTR1AMEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL19043634 | 0.74 | HTR1A (0.56) | HTR1A | |
| SCHEMBL7985198 | 0.74 | MAPT (0.50) | HTR1AMAPK1KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320886-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORP (US) | 2017-06-28 | — | — | EP | disclosed |
| WO-2010014554-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORPORATION (US) | 2010-02-04 | — | — | WO | disclosed |
| WO-2009117150-A2 | METHOD OF TREATING LUPUS WITH CERAMIDE DERIVATIVES | GENZYME CORPORATION (US) | 2009-09-24 | — | — | WO | disclosed |