Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16595231 | 0.76 | LMNA (0.45) | ACSS2KMT2AAGPAT2KDM4EALDH1A1 | |
| SCHEMBL17378554 | 0.76 | KDM4E (0.45) | ACSS2KMT2AAGPAT2BACE1NUDT1 | |
| SCHEMBL16595230 | 0.72 | KDM4E (0.42) | ACSS2KMT2AAGPAT2KDM4EALDH1A1 | |
| SCHEMBL20799418 | 0.72 | AGPAT2 (0.47) | ACSS2KMT2AAGPAT2BACE1KDM4E | |
| SCHEMBL14504050 | 0.72 | KDM4E (0.46) | ACSS2KMT2AAGPAT2BACE1NUDT1 | |
| SCHEMBL17876423 | 0.66 | KMT2A (0.49) | KMT2ABACE1NUDT1KDM4EALDH1A1 | |
| SCHEMBL20670918 | 0.65 | KMT2A (0.43) | KMT2ABACE1NUDT1MAPTSMN1; SMN2 | |
| SCHEMBL17378563 | 0.65 | RAB9A (0.45) | ACSS2KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL3988029 | 0.65 | KMT2A (0.55) | KMT2AAGPAT2BACE1NUDT1KDM4E | |
| SCHEMBL16595229 | 0.64 | LMNA (0.48) | KMT2AAGPAT2KDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3912977-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES | BioMarin Pharmaceutical Inc. (US) | 2021-11-24 | — | — | EP | disclosed |