Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | KLK7 | P49862 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7717487 | 0.84 | MITF (0.70) | MITFSMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL18161382 | 0.81 | MITF (0.66) | MITFSMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL6816157 | 0.80 | MITF (0.65) | MITFSMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL3225051 | 0.75 | MITF (0.53) | MITFNPC1RAB9AMEN1KMT2A | |
| SCHEMBL7297239 | 0.74 | NR1H4 (0.81) | MITFSMN1; SMN2NPC1RAB9ANR1H4 | |
| SCHEMBL3873116 | 0.74 | NR1H4 (0.81) | MITFSMN1; SMN2NPC1RAB9ANR1H4 | |
| SCHEMBL12376581 | 0.74 | MITF (0.56) | MITFNPC1RAB9AKLK7NR1H4 | |
| Hydrochloric Acid SCHEMBL11703876 | 0.73 | MITF (0.51) | MITFNPC1RAB9AMEN1KMT2A | |
| SCHEMBL28288421 | 0.73 | MITF (0.51) | MITFNPC1RAB9AMEN1KMT2A | |
| SCHEMBL17200783 | 0.73 | KMT2A (0.67) | SMN1; SMN2NPC1TP53RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722730-B2 | 5-membered heterocyclic compound | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2014-05-13 | — | — | US | disclosed |
| CN-101821236-B | Five-membered heterocyclic compound | RES FOUND ITSUU LAB | 2013-05-08 | — | — | CN | disclosed |
| US-20110213156-A1 | 5-MEMBERED HETEROCYCLIC COMPOUND | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2011-09-01 | — | — | US | disclosed |
| CN-101821236-A | Five-membered heterocyclic compound | RES FOUND ITSUU LAB | 2010-09-01 | — | — | CN | disclosed |
| EP-2189445-A1 | FIVE-MEMBERED HETEROCYCLIC COMPOUND | Research Foundation Itsuu Laboratory (JP) | 2010-05-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110213156-A1 | 5-MEMBERED HETEROCYCLIC COMPOUND | RXRA, RXRG, RXRB | MITF 694/4885SMN1; SMN2 2833/4885NPC1 692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.