Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.74 |
| ▸ | MPO | P05164 | 6/20 | 0.67 |
| ▸ | HTR1D | P28221 | 4/20 | 0.61 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.60 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | HTR1B | P28222 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | HTR1E | P28566 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | HRH1 | P35367 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2404357 | 0.92 | MPO (0.77) | HTR2AMPOHTR1DTRPM8TRPV1 | |
| SCHEMBL24693252 | 0.88 | HTR2A (0.90) | HTR2AMPOHTR1DTRPM8SLC6A4 | |
| SCHEMBL30053751 | 0.88 | HTR2A (0.90) | HTR2AMPOHTR1DTRPM8SLC6A4 | |
| SCHEMBL24243711 | 0.85 | HTR2A (1.00) | HTR2AMPOHTR1DSLC6A4HTR1A | |
| SCHEMBL30054225 | 0.85 | HTR2A (1.00) | HTR2AMPOHTR1DSLC6A4HTR1A | |
| SCHEMBL2404163 | 0.85 | MPO (0.59) | HTR2AMPOHTR1DTRPM8TRPV1 | |
| SCHEMBL2404720 | 0.84 | HTR6 (0.71) | HTR2AMPOHTR1DTRPM8TRPV1 | |
| Hydrochloric Acid SCHEMBL29765862 | 0.84 | HTR2A (1.00) | HTR2AMPOHTR1DSLC6A4HTR1A | |
| SCHEMBL24694055 | 0.83 | HTR2A (0.81) | HTR2AMPOHTR1DSLC6A4HTR1A | |
| SCHEMBL27817742 | 0.83 | MPO (0.57) | HTR2AMPOHTR1DTRPM8TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212968-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212968-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | HCRTR2, HCRTR1, HRH3 | HTR2A 46/4885MPO 3915/4885HTR1D 71/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.