Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | APEX1 | P27695 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 5/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | CTSB | P07858 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13543619 | 0.78 | MAPT (0.58) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL5579948 | 0.74 | MAPT (0.54) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9742517 | 0.74 | MAPT (0.56) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL1773257 | 0.74 | MAPT (0.54) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL2320353 | 0.74 | POLB (0.65) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL21225484 | 0.74 | MAPT (0.54) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL13052901 | 0.71 | NR4A1 (0.56) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8245249 | 0.70 | CTSB (0.52) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL10405950 | 0.70 | ALDH1A1 (1.00) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8924910 | 0.70 | NPC1 (0.53) | MAPTALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3915557-A1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2021-12-01 | — | — | EP | disclosed |