Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.61 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | TACR1 | P25103 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 3/20 | 0.47 |
| ▸ | MMP1 | P03956 | 3/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | MMP9 | P14780 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10655573 | 0.91 | ITGB3 (0.60) | ITGB3ITGA2BTACR1ALDH1A1MEN1 | |
| SCHEMBL28199355 | 0.91 | ITGB3 (0.60) | ITGB3ITGA2BTACR1ALDH1A1MEN1 | |
| SCHEMBL10654800 | 0.91 | ITGB3 (0.60) | ITGB3ITGA2BTACR1ALDH1A1MEN1 | |
| SCHEMBL2402469 | 0.88 | ITGB3 (0.59) | ITGB3ITGA2BTACR1ALDH1A1MEN1 | |
| SCHEMBL8101144 | 0.88 | ITGB3 (0.59) | ITGB3ITGA2BTACR1ALDH1A1MEN1 | |
| SCHEMBL11507944 | 0.88 | ITGB3 (0.59) | ITGB3ITGA2BATMTACR1MEN1 | |
| SCHEMBL7985057 | 0.85 | ITGB3 (0.56) | ITGB3ITGA2BTACR1MEN1KMT2A | |
| SCHEMBL7970782 | 0.83 | ITGB3 (0.59) | ITGB3ITGA2BTACR1MEN1KMT2A | |
| SCHEMBL7970779 | 0.83 | ITGB3 (0.59) | ITGB3ITGA2BTACR1MEN1KMT2A | |
| SCHEMBL16447882 | 0.82 | PPARG (0.49) | ITGB3ITGA2BMEN1KMT2AMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130244929-A1 | BRIDGED LIPOGLYCOPEPTIDES THAT POTENTIATE THE ACTIVITY OF BETA-LACTAM ANTIBACTERIALS | MERCK SHARP & DOHME CORP. | 2013-09-19 | — | — | US | disclosed |
| WO-2011112441-A1 | BRIDGED LIPOGLYCOPEPTIDES THAT POTENTIATE THE ACTIVITY OF BETA-LACTAM ANTIBACTERIALS | MERCK SHARP & DOHME CORP. (US) | 2011-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130244929-A1 | BRIDGED LIPOGLYCOPEPTIDES THAT POTENTIATE THE ACTIVITY OF BETA-LACTAM ANTIBACTERIALS | SPPL2B, ENGASE, PEPD | ITGB3 3440/4885ITGA2B 2469/4885ATM 4169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.