Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.42 |
| ▸ | MDM4 | O15151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 2/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1325544 | 0.77 | HSD17B10 (0.54) | DYRK1AGSK3BALDH1A1MAP3K14ADRA1A | |
| SCHEMBL3631532 | 0.76 | RAB9A (0.50) | GSK3BALDH1A1 | |
| SCHEMBL31429694 | 0.75 | IDO1 (0.51) | ALDH1A1 | |
| SCHEMBL8542466 | 0.75 | ALDH1A1 (0.49) | GSK3BALDH1A1 | |
| SCHEMBL8537063 | 0.73 | NR4A2 (0.43) | ALDH1A1TP53NR4A2 | |
| SCHEMBL31429733 | 0.73 | IDO1 (0.58) | ALDH1A1 | |
| SCHEMBL29084865 | 0.73 | IDO1 (0.58) | ALDH1A1 | |
| SCHEMBL8541383 | 0.73 | KMO (0.43) | GSK3BALDH1A1 | |
| SCHEMBL28379218 | 0.73 | DYRK1A (0.75) | DYRK1AGSK3BGPR84MAP3K14ALOX5 | |
| SCHEMBL8558526 | 0.72 | NPC1 (0.40) | GSK3BALDH1A1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011106650-A2 | NOVEL P53-MDM2/P53-MDM4 ANTAGONISTS TO TREAT PROLIFERATIVE DISEASE | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2011-09-01 | — | — | WO | disclosed |