Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21946320 | 0.87 | KMT2A (0.46) | L3MBTL1KMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL21946327 | 0.84 | KMT2A (0.48) | KMT2AMAPTALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL21946324 | 0.83 | KMT2A (0.45) | L3MBTL1KMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL24064578 | 0.82 | KMT2A (0.47) | L3MBTL1KMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL24064580 | 0.77 | L3MBTL1 (0.52) | L3MBTL1KMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL24064584 | 0.77 | L3MBTL1 (0.52) | L3MBTL1KMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL21946325 | 0.73 | KMT2A (0.47) | KMT2AMAPTALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL24064581 | 0.72 | KMT2A (0.52) | KMT2AMAPTMEN1USP2LMNA | |
| SCHEMBL25009812 | 0.72 | L3MBTL1 (0.76) | L3MBTL1KMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL30556174 | 0.72 | L3MBTL1 (0.76) | L3MBTL1KMT2AMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210371446-A1 | SIRT1 ACTIVATING COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2021-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210371446-A1 | SIRT1 ACTIVATING COMPOUNDS | SIRT1, SIRT2, SIRT3 | L3MBTL1 2991/4885KMT2A 458/4885MAPT 727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.