Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27348846 | 0.96 | CA12 (0.41) | CA12CA2CA3CA4CA6 | |
| SCHEMBL791912 | 0.92 | ALDH1A1 (0.46) | ALDH1A1KEAP1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL154374 | 0.87 | ALDH1A1 (0.46) | CA12CA2CA9ALDH1A1KEAP1 | |
| SCHEMBL792222 | 0.84 | SIGMAR1 (0.45) | ALDH1A1KEAP1SMN1; SMN2KDM4ESIGMAR1 | |
| SCHEMBL19952594 | 0.84 | CA12 (0.44) | CA12CA2CA3CA4CA6 | |
| SCHEMBL14300251 | 0.84 | ALDH1A1 (0.41) | CA12CA9ALDH1A1KEAP1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7645925 | 0.83 | GLA (0.44) | ALDH1A1KEAP1SMN1; SMN2KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL7645930 | 0.83 | ALDH1A1 (0.43) | ALDH1A1KEAP1SMN1; SMN2KDM4ESIGMAR1 | |
| SCHEMBL2733378 | 0.82 | KEAP1 (0.53) | ALDH1A1KEAP1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL18024043 | 0.82 | CHRM3 (0.40) | ALDH1A1KEAP1SMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11453667-B2 | Pyridone-pyrimidine derivative acting as KRASG12C mutein inhibitor | MEDSHINE DISCOVERY INC. (CN) | 2022-09-27 | — | — | US | disclosed |
| US-20210371411-A1 | PYRIDONE-PYRIMIDINE DERIVATIVE ACTING AS KRASG12C MUTEIN INHIBITOR | MEDSHINE DISCOVERY INC. (CN) | 2021-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11453667-B2 | Pyridone-pyrimidine derivative acting as KRASG12C mutein inhibitor | KRAS, NRAS, MSH2 | CA12 4697/4885CA2 3831/4885CA3 4811/4885 |
| US-20210371411-A1 | PYRIDONE-PYRIMIDINE DERIVATIVE ACTING AS KRASG12C MUTEIN INHIBITOR | KRAS, NRAS, MSH2 | CA12 4697/4885CA2 3831/4885CA3 4811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.