Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL478673 | 0.81 | TSHR (0.48) | ALDH1A1HSD17B10CYP1A2CYP2D6TSHR | |
| SCHEMBL17003212 | 0.80 | PRSS1 (0.44) | ALDH1A1HSD17B10CYP1A2CYP2D6TSHR | |
| SCHEMBL15721458 | 0.80 | AAK1 (0.42) | AAK1ALDH1A1HSD17B10CYP1A2CYP2D6 | |
| SCHEMBL17723 | 0.78 | GAA (0.52) | ALDH1A1HSD17B10CYP1A2CYP2D6TSHR | |
| SCHEMBL9669310 | 0.78 | CYP3A4 (0.49) | ALDH1A1CYP1A2CYP2D6CYP2C19NPSR1 | |
| SCHEMBL13398132 | 0.77 | CYP1A2 (0.42) | ALDH1A1HSD17B10CYP1A2CYP2D6TSHR | |
| SCHEMBL12690674 | 0.77 | AAK1 (0.41) | AAK1ALDH1A1HSD17B10CYP1A2CYP2D6 | |
| SCHEMBL12092169 | 0.77 | AAK1 (0.41) | AAK1ALDH1A1HSD17B10CYP1A2CYP2D6 | |
| SCHEMBL16658953 | 0.77 | TSHR (0.53) | ALDH1A1HSD17B10CYP1A2CYP2D6TSHR | |
| Methane SCHEMBL28846175 | 0.77 | GAA (0.51) | ALDH1A1HSD17B10CYP1A2CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 846 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118005531-A | Synthesis method of chiral unnatural amino acid derivative | 内蒙古大学 | 2024-05-10 | — | — | CN | claimed |
| CN-115260126-B | Chiral quaternary ammonium salt with (S) -binaphthyl, preparation method and application | 湖南城市学院 | 2024-01-30 | — | — | CN | claimed |
| CN-115260126-A | Chiral quaternary ammonium salt with (S) -binaphthyl and preparation method and application thereof | 湖南城市学院 | 2022-11-01 | — | — | CN | claimed |
| CN-114262295-A | Chiral quaternary ammonium salt with spiro indane skeleton and its prepn and application | 天津大学 | 2022-04-01 | — | — | CN | claimed |
| CN-108299482-B | F-BPA and intermediate synthesis method, intermediate and application thereof | 中国原子能科学研究院 | 2020-10-09 | — | — | CN | claimed |
| CN-104263795-A | Method for preparing chiral alpha-naphthenic glycine | SICHUAN TONGSHENG BIOTECHNOLOGY CO LTD | 2015-01-07 | — | — | CN | claimed |
| US-20140294763-A1 | PEPTIDOMIMETIC PROTEASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2014-10-02 | — | — | US | claimed |
| US-20120282219-A1 | PEPTIDOMIMETIC PROTEASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-11-08 | — | — | US | claimed |
| US-20120064034-A1 | Peptidomimetic protease inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-15 | — | — | US | claimed |
| US-20110178302-A1 | NUCLEOPHILIC FLUORINATION OF AROMATIC COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-07-21 | — | — | US | claimed |
| JP-4689938-B2 | — | — | 2011-06-01 | — | — | JP | claimed |
| EP-2307337-A2 | NUCLEOPHILIC FLUORINATION OF AROMATIC COMPOUNDS | The Regents Of The University Of California (US) | 2011-04-13 | — | — | EP | claimed |
| EP-1878720-B1 | Process for preparing chiral bicycloprolinates as intermediates for the preparation of peptidomimetic protease inhibitors | VERTEX PHARMA (US) | 2010-10-06 | — | — | EP | claimed |
| US-20100137583-A1 | Peptidomimetic protease inhibitors | VERTEX PHARMACEUTICALS INCORPORATED | 2010-06-03 | — | — | US | claimed |
| WO-2010008522-A2 | NUCLEOPHILIC FLUORINATION OF AROMATIC COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-01-21 | — | — | WO | claimed |
| EP-1878720-A1 | Process for preparing chiral bicycloprolinates as intermediates for the preparation of peptidomimetic protease inhibitors | Vertex Pharmaceuticals Incorporated (US) | 2008-01-16 | — | — | EP | claimed |
| US-20050197299-A1 | Hepatitis C antiviral agents including telaprevir (VX 950); higher tolerance, reduced side effects; azaheterocyclic amido ketone derivatives | VERTEX PHARMACEUTICALS INCORPORATED | 2005-09-08 | — | — | US | claimed |
| JP-2004517047-A | — | — | 2004-06-10 | — | — | JP | claimed |
| EP-1320540-A2 | PEPTIDOMIMETIC PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-06-25 | — | — | EP | claimed |
| WO-2002018369-A2 | PEPTIDOMIMETIC PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-03-07 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197299-A1 | Hepatitis C antiviral agents including telaprevir (VX 950); higher tolerance, reduced side effects; azaheterocyclic amido ketone derivatives | CTRC, PEPD, CTSC | AAK1 2545/4885ALDH1A1 1451/4885HSD17B10 1793/4885 |
| US-20140294763-A1 | PEPTIDOMIMETIC PROTEASE INHIBITORS | CTSC, PREP, PEPD | AAK1 3561/4885ALDH1A1 2218/4885HSD17B10 2139/4885 |
| US-20100137583-A1 | Peptidomimetic protease inhibitors | CTSC, PREP, PEPD | AAK1 3561/4885ALDH1A1 2218/4885HSD17B10 2139/4885 |
| US-20120064034-A1 | Peptidomimetic protease inhibitors | CTSC, PREP, PEPD | AAK1 3561/4885ALDH1A1 2218/4885HSD17B10 2139/4885 |
| US-20110178302-A1 | NUCLEOPHILIC FLUORINATION OF AROMATIC COMPOUNDS | SLC18A2, AFF4, SLC6A19 | AAK1 4518/4885ALDH1A1 2811/4885HSD17B10 3677/4885 |
| US-20120282219-A1 | PEPTIDOMIMETIC PROTEASE INHIBITORS | CTSC, PEPD, PREP | AAK1 3217/4885ALDH1A1 2639/4885HSD17B10 3170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.