Sugi Predict

Sugi Predict / Compounds / SCHEMBL478673

SCHEMBL478673

SCHEMBL478673

COC(=O)CN=C(c1ccccc1)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 1/20 0.48
▸ ESRRB O95718 1/20 0.46
▸ HSD17B10 Q99714 2/20 0.46
▸ CYP1A2 P05177 1/20 0.46
▸ CYP2D6 P10635 1/20 0.46
▸ AKT1 P31749 1/20 0.45
▸ POLB P06746 1/20 0.43
▸ ALDH1A1 P00352 7/20 0.42
▸ KDM4E B2RXH2 2/20 0.42
▸ LMNA P02545 2/20 0.42
▸ KMT2A Q03164 4/20 0.42
▸ SMN1; SMN2 Q16637 4/20 0.42
▸ RAB9A P51151 2/20 0.42
▸ MAPT P10636 4/20 0.42
▸ MEN1 O00255 2/20 0.42
▸ CYP3A4 P08684 1/20 0.42
▸ HPGD P15428 1/20 0.42
▸ ALOX15 P16050 1/20 0.42
▸ CES1 P23141 1/20 0.42
▸ MAPK1 P28482 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17003212 0.85 PRSS1 (0.44) TSHRHSD17B10CYP1A2CYP2D6POLB
SCHEMBL2738356 0.84 CYP1A2 (0.68) TSHRESRRBHSD17B10CYP1A2CYP2D6
SCHEMBL10155082 0.84 CYP1A2 (0.68) TSHRESRRBHSD17B10CYP1A2CYP2D6
SCHEMBL17723 0.82 GAA (0.52) TSHRHSD17B10CYP1A2CYP2D6ALDH1A1
SCHEMBL13398132 0.81 CYP1A2 (0.42) TSHRHSD17B10CYP1A2CYP2D6ALDH1A1
SCHEMBL16658953 0.81 TSHR (0.53) TSHRHSD17B10CYP1A2CYP2D6POLB
Methane SCHEMBL28846175 0.81 GAA (0.51) TSHRHSD17B10CYP1A2CYP2D6ALDH1A1
Hydrochloric Acid SCHEMBL15648328 0.81 GAA (0.51) TSHRHSD17B10CYP1A2CYP2D6ALDH1A1
SCHEMBL240725 0.81 AAK1 (0.48) TSHRHSD17B10CYP1A2CYP2D6ALDH1A1
SCHEMBL14063469 0.80 GAA (0.41) TSHRHSD17B10CYP1A2CYP2D6ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 417 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115260060-A Synthesis method of (2S) -2-N-fluorenylmethoxycarbonylamino-5, 5-dimethyl norleucine 康化（上海）新药研发有限公司 2022-11-01 — — CN claimed
CN-112939841-A Synthesis method of (2S) -2-N-fluorenylmethoxycarbonylamino-4- (3-chlorphenyl) butyric acid 康化（上海）新药研发有限公司 2021-06-11 — — CN claimed
JP-58150552-A — — None — — JP disclosed
JP-57156453-A — — None — — JP disclosed
EP-4729529-A1 PREPARATION OF PEPTIDE INHIBITOR OF INTERLEUKIN-23 RECEPTOR AND USE THEREOF Xizang Haisco Pharmaceutical Co., Ltd. (CN) 2026-04-22 — — EP disclosed
EP-4384268-B1 SMALL MOLECULE UREA DERIVATIVES AS STING ANTAGONISTS CURADEV PHARMA PVT LTD (IN) 2026-03-18 — — EP disclosed
EP-4709718-A1 6-SUBSTITUTED-3-PHENYL-ISOINDOLIN-1-ONES AS CBL-B INHIBITORS SELECTIVE OVER C-CBL Genentech Inc. (US) 2026-03-18 — — EP disclosed
US-12435028-B2 Processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate CELGENE CORPORATION (US) 2025-10-07 — — US disclosed
US-20250223259-A1 PROTEASE INHIBITORS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION MERCK SHARP & DOHME LLC (US) 2025-07-10 — — US disclosed
US-12336991-B2 Factor XIIA inhibitors UNIVERSITY OF LEEDS (GB) 2025-06-24 — — US disclosed
US-20250197869-A1 Ribosome-Mediated Incorporation of Peptides and Peptidomimetics ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2025-06-19 — — US disclosed
WO-1996022997-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1996-08-01 — — WO disclosed
WO-1995029909-A1 NOVEL ACYCLIC AND CYCLIC AMIDES AS NEUROTRANSMITTER RELEASE ENHANCERS PFIZER INC. (US) 1995-11-09 — — WO disclosed
EP-0037271-B1 INDOLE DERIVATIVES AND PROCESS FOR PREPARING THE SAME TORAY INDUSTRIES, INC. (JP) 1984-01-18 — — EP disclosed
EP-0047516-B1 PROPYLAMINE DERIVATIVE AND PROCESS OF MANUFACTURING THE SAME TORAY INDUSTRIES, INC. (JP) 1984-01-04 — — EP disclosed
JP-S58150552-A BUTANAL DERIVATIVE AND ITS PREPARATION TORAY IND INC 1983-09-07 — — JP disclosed
US-4399289-A STABLE TRYPTOPHANE INTERMEDIATES TORAY INDUSTRIES, INC. (JP) 1983-08-16 — — US disclosed
JP-S57156453-A N-(DIPHENYLMETHYLENE)PROPYLAMINE DERIVATIVE TORAY IND INC 1982-09-27 — — JP disclosed
EP-0047516-A1 Propylamine derivative and process of manufacturing the same TORAY INDUSTRIES, INC. (JP) 1982-03-17 — — EP disclosed
EP-0037271-A1 Indole derivatives and process for preparing the same TORAY INDUSTRIES, INC. (JP) 1981-10-07 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12435028-B2 Processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate UMPS, DHPS, NT5C3B TSHR 1670/4885ESRRB 4448/4885HSD17B10 1426/4885
US-20250223259-A1 PROTEASE INHIBITORS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION ACE2, PRSS2, PRSS1 TSHR 3319/4885ESRRB 3244/4885HSD17B10 933/4885
US-20250197869-A1 Ribosome-Mediated Incorporation of Peptides and Peptidomimetics NPEPPS, DNPEP, AARS1 TSHR 3698/4885ESRRB 2926/4885HSD17B10 4438/4885
US-12336991-B2 Factor XIIA inhibitors F11, F13B, F12 TSHR 2458/4885ESRRB 4142/4885HSD17B10 1103/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.