Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2410911 | 0.99 | CFTR (0.45) | CFTRFGFR1HPGDDYRK1AALDH1A1 | |
| SCHEMBL2405975 | 0.87 | JAK3 (0.46) | CFTRFGFR1ALDH1A1USP2CYP1A2 | |
| SCHEMBL2410186 | 0.85 | MAPT (0.42) | HPGDALDH1A1USP2CYP1A2HSD17B10 | |
| SCHEMBL2408774 | 0.84 | HPGD (0.41) | HPGDALDH1A1USP2CYP1A2HSD17B10 | |
| SCHEMBL2408379 | 0.84 | RPS6KA3 (0.48) | FGFR1HPGDALDH1A1USP2CYP1A2 | |
| SCHEMBL2408100 | 0.83 | RPS6KA3 (0.47) | FGFR1HPGDALDH1A1USP2CYP1A2 | |
| SCHEMBL17802582 | 0.80 | CFTR (0.54) | CFTRFGFR1HPGDDYRK1AALDH1A1 | |
| SCHEMBL2410246 | 0.79 | CFTR (0.63) | CFTRFGFR1HPGDDYRK1ARPS6KA3 | |
| SCHEMBL2408339 | 0.76 | RPS6KA3 (0.48) | HPGDALDH1A1USP2CYP1A2HSD17B10 | |
| SCHEMBL2408398 | 0.76 | PTPN11 (0.41) | ALDH1A1USP2CYP1A2HSD17B10CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011106168-A1 | PURINE COMPOUNDS FOR TREATING AUTOIMMUNE AND DEMYELINATING DISEASES | DCAM PHARMA INC (US) | 2011-09-01 | — | — | WO | claimed |
| WO-2011106168-A1 | PURINE COMPOUNDS FOR TREATING AUTOIMMUNE AND DEMYELINATING DISEASES | DCAM PHARMA INC (US) | 2011-09-01 | — | — | WO | disclosed |
| WO-2011106168-A1 | PURINE COMPOUNDS FOR TREATING AUTOIMMUNE AND DEMYELINATING DISEASES | DCAM PHARMA INC (US) | 2011-09-01 | — | — | WO | disclosed |