Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2408774 | 0.99 | HPGD (0.41) | MAPTMAPK14SCN9AHPGDHDAC6 | |
| SCHEMBL2408339 | 0.90 | RPS6KA3 (0.48) | HPGDPOLBUSP2ALDH1A1CYP1A2 | |
| SCHEMBL2408398 | 0.90 | PTPN11 (0.41) | MAPTMAPK14SCN9AUSP2ALDH1A1 | |
| SCHEMBL2407291 | 0.85 | CFTR (0.46) | MAPTHPGDPOLBUSP2ALDH1A1 | |
| SCHEMBL2410911 | 0.84 | CFTR (0.45) | HPGDPOLBUSP2ALDH1A1CYP1A2 | |
| SCHEMBL2533237 | 0.81 | MKNK1 (0.36) | MAPTMAPK14SCN9AHPGDPOLB | |
| SCHEMBL2533233 | 0.81 | RIPK1 (0.37) | MAPTMAPK14SCN9AHPGDRIPK1 | |
| SCHEMBL2408379 | 0.81 | RPS6KA3 (0.48) | HPGDUSP2ALDH1A1CYP1A2CASP1 | |
| SCHEMBL2409198 | 0.80 | HDAC6 (0.52) | MAPTHPGDHDAC6ALDH1A1HSD17B10 | |
| SCHEMBL2410524 | 0.80 | CFTR (0.47) | MAPTHDAC6POLBRIPK1RIPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011106168-A1 | PURINE COMPOUNDS FOR TREATING AUTOIMMUNE AND DEMYELINATING DISEASES | DCAM PHARMA INC (US) | 2011-09-01 | — | — | WO | claimed |
| WO-2011106168-A1 | PURINE COMPOUNDS FOR TREATING AUTOIMMUNE AND DEMYELINATING DISEASES | DCAM PHARMA INC (US) | 2011-09-01 | — | — | WO | disclosed |
| WO-2011106168-A1 | PURINE COMPOUNDS FOR TREATING AUTOIMMUNE AND DEMYELINATING DISEASES | DCAM PHARMA INC (US) | 2011-09-01 | — | — | WO | disclosed |