Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.36 |
| ▸ | PGR | P06401 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24076862 | 0.88 | MAPT (0.47) | MAPTPRMT5WDR77SMN1; SMN2PARP1 | |
| SCHEMBL24076879 | 0.81 | DAO (0.38) | MAPTPRMT5WDR77ATMNPSR1 | |
| SCHEMBL24076281 | 0.78 | POLB (0.40) | MAPTPRMT5WDR77PGRSMN1; SMN2 | |
| SCHEMBL24076276 | 0.76 | MAPT (0.36) | MAPTPRMT5WDR77PGRSMN1; SMN2 | |
| SCHEMBL24076903 | 0.75 | PRMT5 (0.48) | PRMT5WDR77AURKBATMNPSR1 | |
| SCHEMBL24077199 | 0.75 | HTT (0.47) | PRMT5WDR77SMN1; SMN2HTT | |
| SCHEMBL25430355 | 0.72 | LMNA (0.46) | PRMT5WDR77PARP1ARATM | |
| SCHEMBL24076878 | 0.71 | PARP1 (0.49) | MAPTPRMT5WDR77PGRPARP1 | |
| SCHEMBL30319406 | 0.69 | DAO (0.42) | MAPTPRMT5WDR77PARP1 | |
| SCHEMBL4060640 | 0.69 | ATM (0.57) | MAPTPRMT5PARP1ARATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230202989-A1 | COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-29 | — | — | US | disclosed |
| US-20230202989-A1 | COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-29 | — | — | US | disclosed |
| WO-2021239885-A1 | COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2021-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230202989-A1 | COMPOUNDS | NLRP3, NLRP1, IL1B | MAPT 1004/4885PRMT5 3337/4885WDR77 1820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.