Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4930492 | 0.83 | HDAC2 (0.70) | HDAC1HDAC6HDAC2HDAC3NCOR2 | |
| SCHEMBL14527198 | 0.76 | KDM4E (0.64) | HDAC1HDAC6HDAC2HDAC3DRD2 | |
| SCHEMBL2410827 | 0.76 | HDAC1 (0.56) | HDAC1HDAC6HDAC2HDAC3NCOR2 | |
| SCHEMBL4818126 | 0.76 | DRD2 (0.52) | HDAC1HDAC6HDAC2HDAC3NCOR2 | |
| SCHEMBL31081137 | 0.74 | KDM4E (0.72) | HDAC1HDAC6HDAC2HDAC3DRD2 | |
| SCHEMBL721792 | 0.74 | KDM4E (0.72) | HDAC1HDAC6HDAC2HDAC3DRD2 | |
| SCHEMBL446419 | 0.73 | KDM4E (0.56) | HDAC1HDAC6HDAC2HDAC3NCOR2 | |
| SCHEMBL2407741 | 0.73 | EGFR (0.52) | HDAC1HDAC6DRD2EGFRPIK3CA | |
| SCHEMBL2415976 | 0.73 | HDAC6 (0.49) | HDAC1HDAC6HDAC2HDAC3NCOR2 | |
| SCHEMBL2407908 | 0.72 | LMNA (0.55) | HDAC1HDAC6HDAC2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011106632-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-09-01 | — | — | WO | disclosed |