Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2408848 | 0.79 | TSHR (0.67) | LMNAGAAHDAC6HDAC1HDAC8 | |
| SCHEMBL2415976 | 0.76 | HDAC6 (0.49) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL2410827 | 0.74 | HDAC1 (0.56) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL30791183 | 0.73 | LMNA (0.69) | LMNAGAAHDAC6HDAC1HDAC8 | |
| SCHEMBL29454504 | 0.73 | LMNA (0.59) | LMNAGAAHDAC6HDAC8HDAC3 | |
| SCHEMBL2407744 | 0.72 | HDAC1 (0.58) | GAAHDAC6HDAC1HDAC8HDAC3 | |
| SCHEMBL2407905 | 0.71 | LMNA (0.57) | LMNAGAAHDAC6HDAC1HDAC8 | |
| SCHEMBL5720709 | 0.71 | LMNA (0.64) | LMNAGAAHDAC6HDAC1HDAC3 | |
| SCHEMBL2410188 | 0.71 | HDAC6 (0.44) | LMNAHDAC6HDAC1HDAC8HDAC3 | |
| SCHEMBL3455177 | 0.70 | LMNA (0.54) | LMNAGAAHDAC6HDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011106632-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-09-01 | — | — | WO | disclosed |