Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2407908 | 0.79 | LMNA (0.55) | HDAC1HDAC6HDAC8HDAC3GAA | |
| SCHEMBL2410827 | 0.78 | HDAC1 (0.56) | HDAC1HDAC6HDAC8RAB9AHDAC3 | |
| SCHEMBL2415976 | 0.75 | HDAC6 (0.49) | HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL2410188 | 0.72 | HDAC6 (0.44) | HDAC1HDAC6HDAC8HPGDNPC1 | |
| SCHEMBL1884686 | 0.72 | — | — | |
| SCHEMBL2407744 | 0.71 | HDAC1 (0.58) | HDAC1HDAC6HDAC8ALDH1A1KDM4E | |
| SCHEMBL2411097 | 0.71 | HDAC6 (0.67) | HDAC1HDAC6HDAC8ALDH1A1HPGD | |
| SCHEMBL14454655 | 0.70 | HDAC6 (0.60) | HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL445528 | 0.70 | LMNA (0.70) | HDAC1ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL2405674 | 0.70 | HDAC1 (0.54) | TSHRHDAC1HDAC6HDAC8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011106632-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-09-01 | — | — | WO | disclosed |