Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 2/20 | 0.57 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.57 |
| ▸ | MTHFD2 | P13995 | 6/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC6A7 | Q99884 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12321175 | 0.87 | KCNK3 (0.58) | KCNK3KCNK9MTHFD2P2RX7MAPK1 | |
| SCHEMBL12320789 | 0.86 | KCNK3 (0.60) | KCNK3KCNK9MTHFD2MAPK1HPGD | |
| SCHEMBL12321214 | 0.79 | MTHFD2 (0.61) | KCNK3KCNK9MTHFD2MAPK1HPGD | |
| SCHEMBL2471575 | 0.77 | KCNK3 (0.65) | KCNK3KCNK9MTHFD2MEN1KMT2A | |
| SCHEMBL12321215 | 0.77 | KCNK3 (0.60) | KCNK3KCNK9MTHFD2MAPK1SLC6A7 | |
| SCHEMBL12320843 | 0.76 | KCNK3 (0.55) | KCNK3KCNK9MTHFD2MAPK1HPGD | |
| SCHEMBL2410631 | 0.76 | KCNK3 (0.59) | KCNK3KCNK9MTHFD2MAPK1HPGD | |
| SCHEMBL2410232 | 0.76 | KCNK3 (0.72) | KCNK3KCNK9MTHFD2HPGDMEN1 | |
| SCHEMBL2410478 | 0.76 | KCNK3 (0.73) | KCNK3KCNK9MTHFD2MAPK1MEN1 | |
| SCHEMBL12320841 | 0.76 | SLC6A7 (0.66) | KCNK3KCNK9MTHFD2MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011103715-A1 | TASK CHANNEL ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2011-09-01 | — | — | WO | disclosed |
| WO-2011103715-A1 | TASK CHANNEL ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2011-09-01 | — | — | WO | disclosed |
| WO-2011106276-A1 | TASK CHANNEL ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2011-09-01 | — | — | WO | disclosed |