Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | HPRT1 | P00492 | 2/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.33 |
| ▸ | PNP | P00491 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | HBB | P68871 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.32 |
| ▸ | NT5E | P21589 | 1/20 | 0.32 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.32 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14697559 | 0.86 | DGAT1 (0.38) | DGAT1BRD4CREBBPHPRT1NR3C1 | |
| SCHEMBL15544850 | 0.83 | BRD4 (0.37) | DGAT1BRD4CREBBPHPRT1NR3C1 | |
| SCHEMBL15560648 | 0.83 | NR3C1 (0.33) | DGAT1BRD4CREBBPHPRT1NR3C1 | |
| SCHEMBL14697499 | 0.82 | NR3C1 (0.45) | HPRT1NR3C1TSHR | |
| SCHEMBL26640909 | 0.79 | DGAT1 (0.41) | DGAT1BRD4CREBBPHPRT1PNP | |
| SCHEMBL357273 | 0.78 | FDPS (0.45) | ENPP1NT5E | |
| SCHEMBL31340868 | 0.78 | FDPS (0.45) | ENPP1NT5E | |
| SCHEMBL16977995 | 0.78 | DGAT1 (0.38) | DGAT1HSP90AA1BRD4CREBBP | |
| SCHEMBL18975732 | 0.77 | HPRT1 (0.35) | DGAT1BRD4CREBBPHPRT1PNP | |
| SCHEMBL30907555 | 0.77 | BRD4 (0.35) | DGAT1BRD4CREBBPHPRT1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840534-B2 | Substituted tricyclic compounds as FGFR inhibitors | INCYTE CORPORATION (US) | 2023-12-12 | — | — | US | disclosed |
| US-20210380587-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS | INCYTE HOLDINGS CORPORATION | 2021-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11840534-B2 | Substituted tricyclic compounds as FGFR inhibitors | FGFR3, FGFR1, FGFR2 | DGAT1 1357/4885HSP90AA1 1446/4885HSP90AB1 941/4885 |
| US-20210380587-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS | FGFR3, FGFR1, FGFR2 | DGAT1 1357/4885HSP90AA1 1446/4885HSP90AB1 941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.