Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 10/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20095590 | 0.88 | RIPK1 (0.43) | RIPK1MAPTHPGDATAD2CREBBP | |
| SCHEMBL21221071 | 0.83 | RIPK1 (0.42) | RIPK1ATAD2CREBBP | |
| SCHEMBL21220777 | 0.83 | RIPK1 (0.42) | RIPK1ATAD2CREBBP | |
| SCHEMBL20095517 | 0.83 | RIPK1 (0.42) | RIPK1ATAD2CREBBP | |
| SCHEMBL20095361 | 0.83 | RIPK1 (0.42) | RIPK1ATAD2CREBBP | |
| SCHEMBL24094079 | 0.82 | RIPK1 (0.44) | RIPK1MAPTHPGD | |
| SCHEMBL24094058 | 0.80 | RIPK1 (0.46) | RIPK1MAPTHPGD | |
| SCHEMBL21220912 | 0.76 | RIPK1 (0.39) | RIPK1 | |
| SCHEMBL26493269 | 0.74 | SRD5A1 (0.41) | RIPK1MAPTHPGD | |
| SCHEMBL13502655 | 0.72 | DRD4 (0.48) | RIPK1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3526219-B1 | BICYCLIC PYRIDONE LACTAMS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2021-12-15 | — | — | EP | disclosed |