Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 8/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24094079 | 0.86 | RIPK1 (0.44) | RIPK1MAPTHPGDBMPR1AACVRL1 | |
| SCHEMBL20095387 | 0.86 | RIPK1 (0.45) | RIPK1BACE1BACE2BMPR1AACVRL1 | |
| SCHEMBL21220649 | 0.86 | RIPK1 (0.45) | RIPK1BACE1BACE2BMPR1AACVRL1 | |
| SCHEMBL20095598 | 0.86 | RIPK1 (0.45) | RIPK1BACE1BACE2BMPR1AACVRL1 | |
| SCHEMBL20095390 | 0.86 | RIPK1 (0.45) | RIPK1BACE1BACE2BMPR1AACVRL1 | |
| SCHEMBL20095546 | 0.81 | RIPK1 (0.42) | RIPK1BACE1BACE2BMPR1AACVRL1 | |
| SCHEMBL24094029 | 0.80 | RIPK1 (0.43) | RIPK1MAPTHPGD | |
| SCHEMBL20095886 | 0.80 | BMPR1A (0.43) | RIPK1BACE1BACE2BMPR1AACVRL1 | |
| SCHEMBL20095890 | 0.74 | RIPK1 (0.55) | RIPK1 | |
| SCHEMBL20095565 | 0.74 | RIPK1 (0.55) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3526219-B1 | BICYCLIC PYRIDONE LACTAMS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2021-12-15 | — | — | EP | disclosed |