Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.31 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.31 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.31 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.31 |
| ▸ | DRD4 | P21917 | 2/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24094029 | 0.88 | RIPK1 (0.43) | RIPK1MAPTHPGDATAD2CREBBP | |
| SCHEMBL21220781 | 0.83 | RIPK1 (0.42) | RIPK1ATAD2BMPR1BBMPR1AACVRL1 | |
| SCHEMBL21220899 | 0.83 | RIPK1 (0.42) | RIPK1ATAD2BMPR1BBMPR1AACVRL1 | |
| SCHEMBL21221043 | 0.83 | RIPK1 (0.42) | RIPK1ATAD2BMPR1BBMPR1AACVRL1 | |
| SCHEMBL21220936 | 0.83 | RIPK1 (0.42) | RIPK1ATAD2BMPR1BBMPR1AACVRL1 | |
| SCHEMBL21221065 | 0.76 | RIPK1 (0.39) | RIPK1 | |
| SCHEMBL24094079 | 0.74 | RIPK1 (0.44) | RIPK1MAPTHPGDBMPR1BBMPR1A | |
| SCHEMBL13502655 | 0.72 | DRD4 (0.48) | RIPK1MAPTHPGDDRD4DRD2 | |
| SCHEMBL21220902 | 0.72 | BMPR1B (0.44) | RIPK1BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL24094058 | 0.72 | RIPK1 (0.46) | RIPK1MAPTHPGDBMPR1AACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3526219-B1 | BICYCLIC PYRIDONE LACTAMS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2021-12-15 | — | — | EP | disclosed |
| WO-2018073193-A1 | BICYCLIC PYRIDONE LACTAMS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2018-04-26 | — | — | WO | disclosed |