SCHEMBL24095545 — predicted protein targets

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	TRPC5	Q9UL62	3/20	0.38

▸	TRPC4	Q9UBN4	2/20	0.38

▸	TRPC1	P48995	1/20	0.38

▸	MDM2	Q00987	6/20	0.38

▸	KCNH2	Q12809	1/20	0.36

▸	P2RX3	P56373	6/20	0.36

▸	USP1	O94782	2/20	0.34

▸	ADORA3	P0DMS8	2/20	0.33

▸	GPBAR1	Q8TDU6	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL20652966	0.93	MDM2 (0.43)	TRPC5TRPC4TRPC1MDM2KCNH2
SCHEMBL20656196	0.92	MDM2 (0.39)	TRPC5TRPC4TRPC1MDM2KCNH2
SCHEMBL20652731	0.89	PKM (0.40)	TRPC5TRPC4TRPC1MDM2KCNH2
SCHEMBL20652803	0.89	P2RX3 (0.41)	TRPC5TRPC4TRPC1KCNH2P2RX3
SCHEMBL20652804	0.88	P2RX3 (0.46)	TRPC5TRPC4TRPC1KCNH2P2RX3
SCHEMBL20653072	0.88	ADORA3 (0.42)	TRPC5TRPC4KCNH2P2RX3USP1
SCHEMBL20652798	0.86	TRPC4 (0.38)	TRPC5TRPC4TRPC1MDM2KCNH2
SCHEMBL20656195	0.86	TRPC4 (0.38)	TRPC5TRPC4TRPC1MDM2KCNH2
SCHEMBL20652951	0.86	FFAR4 (0.36)	TRPC5TRPC4TRPC1MDM2KCNH2
SCHEMBL24095606	0.86	MDM2 (0.43)	MDM2P2RX3USP1ADORA3GPBAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-3652176-B1	SUBSTITUTED XANTHINE DERIVATIVES	BOEHRINGER INGELHEIM INT (DE)	2021-12-15	—	—	EP	disclosed