Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.48 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 3/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16790930 | 0.80 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2LMNAHDAC3 | |
| SCHEMBL19174541 | 0.78 | CTSL (0.62) | NPC1RAB9ASMN1; SMN2LMNACTSK | |
| SCHEMBL28105060 | 0.77 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2LMNATSHR | |
| SCHEMBL27621693 | 0.77 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2LMNATSHR | |
| SCHEMBL8773507 | 0.77 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2LMNATSHR | |
| SCHEMBL28969034 | 0.77 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2LMNATSHR | |
| SCHEMBL29106946 | 0.77 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2LMNATSHR | |
| SCHEMBL28969065 | 0.77 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2LMNATSHR | |
| SCHEMBL26310723 | 0.76 | CTSK (0.52) | NPC1RAB9ASMN1; SMN2LMNACHRNB2 | |
| SCHEMBL5803249 | 0.76 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252640-A1 | ASPARAGINE DERIVATIVES AND METHODS OF USING SAME | SENDA BIOSCIENCES, INC. (US) | 2021-12-16 | — | — | WO | disclosed |