Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.58 |
| ▸ | MAP2 | P11137 | 1/20 | 0.57 |
| ▸ | PPARG | P37231 | 5/20 | 0.55 |
| ▸ | MPO | P05164 | 2/20 | 0.52 |
| ▸ | APOL1 | O14791 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
| ▸ | TUBB | P07437 | 1/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.48 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.48 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.48 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24098682 | 0.92 | PPARG (0.59) | TACR1MAP2PPARGMPOAPOL1 | |
| SCHEMBL6929600 | 0.91 | PPARG (0.66) | TACR1MAP2PPARGAPOL1EGFR | |
| SCHEMBL7231716 | 0.86 | PPARG (0.60) | TACR1MAP2PPARGEGFR | |
| SCHEMBL22160213 | 0.85 | EGFR (0.62) | PPARGAPOL1EGFRSRC | |
| SCHEMBL24098678 | 0.84 | PPARG (0.66) | TACR1PPARGAPOL1EGFR | |
| SCHEMBL30218312 | 0.84 | PPARG (0.66) | TACR1PPARGAPOL1EGFR | |
| SCHEMBL24099201 | 0.83 | TACR1 (0.55) | TACR1PPARGAPOL1EGFRSRC | |
| SCHEMBL28906368 | 0.81 | KDM4E (0.51) | TACR1MAP2PPARGPTGS2TUBB4A | |
| SCHEMBL22161253 | 0.81 | TACR1 (0.49) | TACR1PPARGPTGS2TUBB4ATUBB | |
| SCHEMBL22160189 | 0.81 | GPR17 (0.57) | TACR1PPARGEGFRSRCTUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230014907-A1 | INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED | 2023-01-19 | — | — | US | disclosed |
| WO-2021252849-A1 | INHIBITORS OF APOL1 AND USE OF THE SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2021-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230014907-A1 | INHIBITORS OF APOL1 AND METHODS OF USING SAME | APOL1, APOB, NPC1L1 | TACR1 3857/4885MAP2 4302/4885PPARG 2747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.