Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.48 |
| ▸ | TUBB | P07437 | 6/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.48 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.48 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28906422 | 0.87 | LMNA (0.51) | LMNAHPGDCNR1TUBB4ATUBB | |
| SCHEMBL6929600 | 0.82 | PPARG (0.66) | KDM4EALDH1A1TUBB4ATUBBTUBA3C | |
| SCHEMBL6823933 | 0.82 | HTR2A (0.72) | HPGDHTR2AHTR2CTACR1PPARG | |
| SCHEMBL22161253 | 0.82 | TACR1 (0.49) | KDM4EALDH1A1LMNAHPGDPTGS2 | |
| SCHEMBL28906353 | 0.81 | HTR2A (0.61) | KDM4EALDH1A1HPGDPTGS2CNR1 | |
| SCHEMBL28906516 | 0.81 | HTR2A (0.62) | CNR1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL28906438 | 0.81 | TUBB4A (0.67) | KDM4EALDH1A1PTGS2TUBB4ATUBB | |
| SCHEMBL30046753 | 0.81 | HTR2A (0.64) | KDM4EALDH1A1LMNAHPGDCNR1 | |
| SCHEMBL28906447 | 0.81 | TUBB4A (0.67) | KDM4EALDH1A1PTGS2GAATUBB4A | |
| SCHEMBL28906379 | 0.81 | HPGD (0.63) | KDM4EALDH1A1LMNAHPGDPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115304533-B | Bisindolemethane type alpha-glucosidase inhibitor and preparation method and application thereof | 中国医学科学院药用植物研究所云南分所 | 2024-04-12 | — | — | CN | disclosed |
| CN-117567447-A | Thiophene-containing bis-indolomethane type a-glucosidase inhibitor and preparation method and application thereof | 中国医学科学院药用植物研究所云南分所 | 2024-02-20 | — | — | CN | disclosed |
| CN-115304533-A | Bis-indole methane type alpha-glucosidase inhibitor and preparation method and application thereof | 中国医学科学院药用植物研究所云南分所 | 2022-11-08 | — | — | CN | disclosed |