Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30874417 | 1.00 | ABL1 (0.37) | ABL1KDM4EALDH1A1LMNAHSD17B10 | |
| SCHEMBL24100076 | 0.83 | KDM4E (0.38) | KDM4EALDH1A1LMNAHSD17B10GLA | |
| SCHEMBL22225989 | 0.82 | AR (0.36) | KDM4EALDH1A1HSD17B10GAAAR | |
| SCHEMBL1340430 | 0.80 | ALOX5 (0.45) | KDM4EALDH1A1LMNAHSD17B10POLB | |
| SCHEMBL7269670 | 0.78 | SERPINH1 (0.40) | ABL1KDM4EALDH1A1LMNAHSD17B10 | |
| SCHEMBL27432579 | 0.75 | EGFR (0.37) | ALDH1A1LMNAHSD17B10GAAAR | |
| SCHEMBL22226359 | 0.75 | HPGD (0.42) | KDM4EALDH1A1LMNAHSD17B10GLA | |
| SCHEMBL31170811 | 0.73 | NOTUM (0.50) | ALDH1A1HSD17B10GAAAREGFR | |
| SCHEMBL22225985 | 0.73 | KDM4E (0.39) | KDM4EALDH1A1LMNAHSD17B10GAA | |
| SCHEMBL29323701 | 0.73 | KDM4E (0.36) | KDM4EALDH1A1LMNAHSD17B10GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113226310-B | 15-PGDH inhibitors | 杏林制药株式会社 | 2024-03-19 | — | — | CN | disclosed |
| EP-3922247-A1 | 15-PGDH INHIBITOR | Kyorin Pharmaceutical Co., Ltd. (JP) | 2021-12-15 | — | — | EP | disclosed |
| CN-113226310-A | 15-PGDH inhibitors | 杏林制药株式会社 | 2021-08-06 | — | — | CN | disclosed |