Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.32 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24100076 | 0.87 | KDM4E (0.38) | KDM4EALDH1A1HSD17B10LMNAMAPT | |
| SCHEMBL22207633 | 0.81 | HPGD (0.48) | KDM4EALDH1A1HSD17B10LMNAGAA | |
| SCHEMBL15962081 | 0.79 | SELL (0.39) | KDM4EALDH1A1HSD17B10MAPTTDP1 | |
| SCHEMBL22225989 | 0.78 | AR (0.36) | KDM4EALDH1A1HSD17B10MAPTAR | |
| SCHEMBL1340046 | 0.74 | ALOX5 (0.40) | KDM4EALDH1A1HSD17B10MAPTTDP1 | |
| SCHEMBL7318609 | 0.74 | HSD17B10 (0.36) | KDM4EALDH1A1HSD17B10LMNAPOLB | |
| SCHEMBL30874417 | 0.73 | ABL1 (0.37) | KDM4EALDH1A1HSD17B10LMNAAR | |
| SCHEMBL24099704 | 0.73 | ABL1 (0.37) | KDM4EALDH1A1HSD17B10LMNAAR | |
| SCHEMBL27435302 | 0.71 | ALDH1A1 (0.44) | KDM4EALDH1A1HSD17B10LMNAMAPT | |
| SCHEMBL28947224 | 0.70 | KDM4E (0.36) | KDM4EALDH1A1HSD17B10LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3922247-A1 | 15-PGDH INHIBITOR | Kyorin Pharmaceutical Co., Ltd. (JP) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020145250-A1 | 15-PGDH INHIBITOR | 杏林製薬株式会社 | 2020-07-16 | — | — | WO | disclosed |