Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 12/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 12/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8477454 | 0.89 | PDCD1 (0.36) | AGTR1AGTR2LTB4R2 | |
| SCHEMBL8472443 | 0.86 | LTB4R2 (0.37) | AGTR1AGTR2LTB4R2 | |
| SCHEMBL8472867 | 0.84 | LTB4R2 (0.40) | AGTR1AGTR2LTB4R2 | |
| SCHEMBL3512 | 0.79 | LTB4R2 (0.39) | AGTR1AGTR2LTB4R2 | |
| SCHEMBL6961466 | 0.77 | TNKS (0.54) | TNKSTNKS2 | |
| SCHEMBL6080556 | 0.76 | AGTR1 (0.38) | TNKSTNKS2AGTR1AGTR2 | |
| SCHEMBL9709552 | 0.74 | IAPP (0.40) | AGTR1AGTR2LTB4R2 | |
| SCHEMBL1886315 | 0.74 | TRPM8 (0.39) | TNKSTNKS2AGTR1 | |
| SCHEMBL6080549 | 0.74 | CCR6 (0.42) | TNKSTNKS2 | |
| SCHEMBL2819270 | 0.74 | TRPM8 (0.39) | TNKSTNKS2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |