Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | BRS3 | P32247 | 2/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9709753 | 0.93 | LTB4R2 (0.42) | IAPPLTB4R2AGTR1BRS3AGTR2 | |
| SCHEMBL9709732 | 0.92 | LTB4R2 (0.41) | IAPPLTB4R2AGTR1BRS3AGTR2 | |
| SCHEMBL9709582 | 0.92 | IAPP (0.39) | IAPPMMP12CNR2LTB4R2AGTR1 | |
| SCHEMBL6961100 | 0.85 | NPC1 (0.39) | AGTR1AGTR2 | |
| SCHEMBL6953051 | 0.82 | HSD11B1 (0.47) | AGTR1BRS3AGTR2 | |
| SCHEMBL6956494 | 0.81 | TDP1 (0.40) | BRS3 | |
| SCHEMBL6949197 | 0.80 | HSD11B1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL6957300 | 0.80 | HSD11B1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL9709499 | 0.80 | HSD11B1 (0.36) | LTB4R2AGTR1FFAR1BRS3AGTR2 | |
| SCHEMBL8315967 | 0.80 | AGTR1 (0.40) | LTB4R2AGTR1BRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157040-A | Treatment of hypertension, ocular hypertension and some CNS disorders | MERCK & CO., INC. (US) | 1992-10-20 | — | — | US | disclosed |
| EP-0507594-A1 | Substituted quinolines as angiotensin II antagonists | MERCK & CO. INC. (US) | 1992-10-07 | — | — | EP | disclosed |