Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24101693 | 0.83 | CCNK (0.70) | TDP1MAPK1GAAKMT2APOLB | |
| SCHEMBL24101404 | 0.83 | CCNK (0.52) | TDP1MAPK1GAAKMT2APOLB | |
| SCHEMBL24101416 | 0.80 | GAA (0.66) | TDP1MAPK1GAAKMT2APOLB | |
| SCHEMBL191582 | 0.79 | ALDH1A1 (0.57) | TDP1GAAKMT2AMEN1HTT | |
| SCHEMBL24101952 | 0.79 | MEN1 (0.52) | TDP1MAPK1GAAKMT2AMEN1 | |
| SCHEMBL24101951 | 0.78 | LMNA (0.57) | TDP1MAPK1GAAKMT2AMEN1 | |
| SCHEMBL24101421 | 0.77 | MAPT (0.77) | TDP1GAAKMT2APOLBMEN1 | |
| SCHEMBL9232215 | 0.76 | GAA (1.00) | MAPK1GAAKMT2APOLBMEN1 | |
| SCHEMBL6520420 | 0.76 | GAA (0.77) | MAPK1GAAKMT2APOLBMEN1 | |
| SCHEMBL7503570 | 0.76 | GAA (0.77) | MAPK1GAAKMT2APOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021249517-A1 | A MOLECULAR GLUE REGULATING CDK12-DDB1 INTERACTION TO TRIGGER CYCLIN K DEGRADATION | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-12-16 | — | — | WO | disclosed |