Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 2/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.52 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 8/20 | 0.49 |
| ▸ | NPC1 | O15118 | 8/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24101693 | 0.86 | CCNK (0.70) | CCNKDDB1CDK12MEN1NPC1 | |
| SCHEMBL24101409 | 0.83 | TDP1 (0.65) | MEN1KMT2AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL24101951 | 0.81 | LMNA (0.57) | CCNKDDB1CDK12MEN1NPC1 | |
| SCHEMBL24101952 | 0.80 | MEN1 (0.52) | CCNKDDB1CDK12MEN1NPC1 | |
| SCHEMBL24101683 | 0.80 | MEN1 (0.61) | CCNKDDB1CDK12MEN1NPC1 | |
| SCHEMBL24101680 | 0.78 | MAPT (0.50) | CCNKDDB1CDK12MEN1NPC1 | |
| SCHEMBL24101692 | 0.77 | MAPT (0.65) | CCNKDDB1CDK12MEN1NPC1 | |
| SCHEMBL24101708 | 0.77 | ALDH1A1 (0.49) | CCNKDDB1CDK12MEN1NPC1 | |
| SCHEMBL24101625 | 0.72 | CCNK (0.78) | CCNKDDB1CDK12MEN1NPC1 | |
| SCHEMBL24101721 | 0.71 | CCNK (0.73) | CCNKDDB1CDK12MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021249517-A1 | A MOLECULAR GLUE REGULATING CDK12-DDB1 INTERACTION TO TRIGGER CYCLIN K DEGRADATION | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-12-16 | — | — | WO | disclosed |