Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | CTPS1 | P17812 | 7/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.55 |
| ▸ | KDM1A | O60341 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24101406 | 0.85 | MAPT (0.70) | MAPTGAACTPS1RAB9ALMNA | |
| SCHEMBL24101692 | 0.82 | MAPT (0.65) | MAPTGAACTPS1RAB9ALMNA | |
| SCHEMBL4933637 | 0.81 | MAPT (0.47) | MAPTGAACTPS1MEN1KMT2A | |
| SCHEMBL24101421 | 0.81 | MAPT (0.77) | MAPTGAACTPS1LMNAMEN1 | |
| SCHEMBL24101691 | 0.79 | MAPT (0.70) | MAPTCTPS1RAB9ALMNAMEN1 | |
| SCHEMBL3956903 | 0.76 | MEN1 (0.65) | MAPTGAARAB9ALMNAMEN1 | |
| SCHEMBL24101768 | 0.75 | MAPT (0.79) | MAPTGAACTPS1RAB9ALMNA | |
| SCHEMBL24101681 | 0.75 | PDE5A (0.70) | RAB9ALMNAMEN1KMT2ANPC1 | |
| SCHEMBL17207741 | 0.75 | MEN1 (1.00) | MAPTGAARAB9ALMNAMEN1 | |
| SCHEMBL27586973 | 0.74 | FFAR2 (0.47) | GAARAB9ALMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021249517-A1 | A MOLECULAR GLUE REGULATING CDK12-DDB1 INTERACTION TO TRIGGER CYCLIN K DEGRADATION | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-12-16 | — | — | WO | disclosed |