Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.45 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.44 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14069855 | 0.89 | KCNJ5 (0.56) | MAPTKMT2AMEN1DHODHGRM4 | |
| SCHEMBL14069860 | 0.87 | BLM (0.49) | MAPTKMT2AMEN1DHODHGRM4 | |
| SCHEMBL14069895 | 0.85 | MAPT (0.52) | MAPTKMT2AMEN1DHODHKCNJ5 | |
| SCHEMBL14069875 | 0.85 | MAPT (0.53) | MAPTKMT2AMEN1DHODHGRM4 | |
| SCHEMBL14640549 | 0.85 | CYP1A2 (0.53) | MAPTKMT2AMEN1DHODHKCNJ5 | |
| SCHEMBL4933898 | 0.85 | DHODH (0.52) | MAPTKMT2AMEN1DHODHKCNJ5 | |
| SCHEMBL5591452 | 0.84 | MAPT (0.54) | MAPTKMT2AMEN1DHODHGRM4 | |
| SCHEMBL14070045 | 0.84 | DHODH (0.51) | MAPTKMT2AMEN1DHODHKCNJ5 | |
| SCHEMBL4929143 | 0.83 | MAPT (0.51) | MAPTKMT2AMEN1DHODHKCNJ5 | |
| SCHEMBL14069894 | 0.83 | DHODH (0.52) | MAPTKMT2AMEN1DHODHKCNJ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221088-A1 | 3,4-Substituted Thiazoles as Ampk Activators | DR. REDDY'S LABORATORIES LTD. (IN) | 2008-09-11 | — | — | US | disclosed |
| US-20080221088-A1 | 3,4-Substituted Thiazoles as Ampk Activators | DR. REDDY'S LABORATORIES LTD. (IN) | 2008-09-11 | — | — | US | disclosed |
| US-20080221088-A1 | 3,4-Substituted Thiazoles as Ampk Activators | DR. REDDY'S LABORATORIES LTD. (IN) | 2008-09-11 | — | — | US | disclosed |
| WO-2007002461-A1 | 3,4-SUBSTITUTED THIAZOLES AS AMPK ACTIVATORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221088-A1 | 3,4-Substituted Thiazoles as Ampk Activators | PRKAG3, PRKAG1, PRKAG2 | MAPT 2742/4885KMT2A 3233/4885MEN1 4274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.