Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | GAA | P10253 | 3/20 | 0.65 |
| ▸ | CTPS1 | P17812 | 7/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | KDM1A | O60341 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CCNK | O75909 | 1/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.48 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24101683 | 0.87 | MEN1 (0.61) | MAPTGAACTPS1LMNARAB9A | |
| SCHEMBL24101406 | 0.85 | MAPT (0.70) | MAPTGAACTPS1LMNARAB9A | |
| SCHEMBL24101421 | 0.83 | MAPT (0.77) | MAPTGAACTPS1LMNAHTT | |
| SCHEMBL24101679 | 0.82 | MAPT (0.67) | MAPTGAACTPS1LMNARAB9A | |
| SCHEMBL24101680 | 0.81 | MAPT (0.50) | MAPTGAALMNARAB9AHTT | |
| SCHEMBL24101768 | 0.78 | MAPT (0.79) | MAPTGAACTPS1LMNARAB9A | |
| SCHEMBL24101404 | 0.77 | CCNK (0.52) | MAPTGAALMNARAB9AHTT | |
| SCHEMBL4041341 | 0.76 | GAA (0.66) | MAPTGAALMNARAB9AHTT | |
| SCHEMBL24101686 | 0.72 | PDE5A (0.63) | MAPTGAACTPS1LMNARAB9A | |
| SCHEMBL24101742 | 0.72 | CCNK (0.72) | MAPTGAACTPS1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021249517-A1 | A MOLECULAR GLUE REGULATING CDK12-DDB1 INTERACTION TO TRIGGER CYCLIN K DEGRADATION | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-12-16 | — | — | WO | disclosed |