Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 9/20 | 0.50 |
| ▸ | TP53 | P04637 | 8/20 | 0.50 |
| ▸ | LMNA | P02545 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.50 |
| ▸ | RELA | Q04206 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 2/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24101943 | 0.83 | NPC1 (0.56) | RAB9AKMT2ANPC1TP53LMNA | |
| SCHEMBL24101792 | 0.77 | RAB9A (0.54) | RAB9AKMT2ANPC1TP53LMNA | |
| SCHEMBL24101791 | 0.72 | LMNA (0.56) | RAB9AKMT2ANPC1TP53LMNA | |
| SCHEMBL24101956 | 0.72 | LMNA (0.58) | RAB9AKMT2ANPC1TP53LMNA | |
| SCHEMBL24101951 | 0.71 | LMNA (0.57) | RAB9AKMT2ANPC1TP53LMNA | |
| SCHEMBL16562034 | 0.69 | ALDH1A1 (0.79) | RAB9AKMT2ANPC1TP53LMNA | |
| SCHEMBL14631274 | 0.69 | MAPT (0.71) | RAB9AKMT2ANPC1TP53LMNA | |
| SCHEMBL14807083 | 0.69 | RAB9A (0.75) | RAB9AKMT2ANPC1TP53LMNA | |
| SCHEMBL14654072 | 0.69 | RAB9A (0.71) | RAB9AKMT2ANPC1TP53LMNA | |
| SCHEMBL3109465 | 0.68 | NPC1 (0.77) | RAB9AKMT2ANPC1TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021249517-A1 | A MOLECULAR GLUE REGULATING CDK12-DDB1 INTERACTION TO TRIGGER CYCLIN K DEGRADATION | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-12-16 | — | — | WO | disclosed |