Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 2/20 | 0.55 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.55 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.55 |
| ▸ | ITGAV | P06756 | 1/20 | 0.55 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.55 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.55 |
| ▸ | ITGAL | P20701 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SLC6A12 | P48065 | 6/20 | 0.36 |
| ▸ | SLC6A11 | P48066 | 6/20 | 0.36 |
| ▸ | SLC6A13 | Q9NSD5 | 5/20 | 0.36 |
| ▸ | SLC6A1 | P30531 | 3/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9312522 | 0.80 | ITGB1 (0.53) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL630436 | 0.74 | ITGB1 (0.54) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL10962660 | 0.71 | ITGB1 (0.52) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL11032630 | 0.71 | — | — | |
| SCHEMBL11212045 | 0.71 | — | — | |
| SCHEMBL2723878 | 0.71 | ITGB1 (0.50) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL4532111 | 0.71 | ITGB1 (0.50) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL23002164 | 0.71 | ITGB1 (0.41) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL6603075 | 0.68 | SLC6A1 (0.50) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL10248614 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252859-A1 | INHIBITORS OF APOL1 AND USE OF THE SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2021-12-16 | — | — | WO | disclosed |