Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 7/20 | 0.48 |
| ▸ | ELANE | P08246 | 2/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.47 |
| ▸ | CTSS | P25774 | 4/20 | 0.46 |
| ▸ | CTSL | P07711 | 3/20 | 0.46 |
| ▸ | CTSB | P07858 | 2/20 | 0.46 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14317559 | 0.84 | ATM (0.54) | ATMCTSKELANECTRB1CTSS | |
| SCHEMBL16473698 | 0.84 | ATM (0.54) | ATMCTSKELANECTRB1CTSS | |
| SCHEMBL14247228 | 0.84 | ATM (0.54) | ATMCTSKELANECTRB1CTSS | |
| SCHEMBL28677738 | 0.80 | CTRB1 (0.52) | ATMCTSKCTRB1CTSSCTSL | |
| SCHEMBL10535416 | 0.79 | KYNU (0.59) | TRPM8CTSKCTSSCTSLCTSB | |
| SCHEMBL22469435 | 0.79 | ATM (0.52) | ATMTRPM8CTSKELANECTRB1 | |
| SCHEMBL14405782 | 0.79 | ALDH1A1 (0.57) | ATMCTSKCTSSCTSLCTSB | |
| SCHEMBL22469281 | 0.79 | ATM (0.52) | ATMTRPM8CTSKELANECTRB1 | |
| SCHEMBL14318309 | 0.79 | SYK (0.59) | ATMCTSKELANECTRB1CTSS | |
| SCHEMBL2519860 | 0.79 | KYNU (0.59) | TRPM8CTSKCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252859-A1 | INHIBITORS OF APOL1 AND USE OF THE SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2021-12-16 | — | — | WO | disclosed |