Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | EDNRB | P24530 | 1/20 | 0.31 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17194951 | 0.84 | PDE2A (0.48) | PDE2AALDH1A1KDM4ECYP1A2POLB | |
| SCHEMBL31708108 | 0.81 | PDE2A (0.51) | PDE2AALDH1A1KDM4ECYP1A2POLB | |
| SCHEMBL26049721 | 0.80 | MAPT (0.37) | CYP1A2POLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL13012210 | 0.78 | GAA (0.50) | PDE2AALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL24940652 | 0.78 | ALDH1A1 (0.42) | PDE2AALDH1A1KDM4ECYP1A2POLB | |
| SCHEMBL423183 | 0.76 | PDE2A (0.61) | PDE2AALDH1A1KDM4ECYP1A2POLB | |
| SCHEMBL25584937 | 0.73 | ALDH1A1 (0.41) | PDE2AALDH1A1KDM4ECYP1A2POLB | |
| SCHEMBL9912008 | 0.71 | PDE2A (0.52) | PDE2AALDH1A1KDM4ECYP1A2POLB | |
| SCHEMBL25583833 | 0.71 | ALDH1A1 (0.39) | PDE2AALDH1A1KDM4ECYP1A2POLB | |
| SCHEMBL29450819 | 0.70 | PDE2A (0.55) | PDE2AALDH1A1KDM4ECYP1A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252307-A1 | RIPK1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2021-12-16 | — | — | WO | disclosed |