Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | DRD4 | P21917 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.52 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.51 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.50 |
| ▸ | PRCP | P42785 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14207950 | 0.93 | DRD2 (0.63) | DRD2DRD4DRD3HTTCARM1 | |
| SCHEMBL24019673 | 0.86 | HTT (0.54) | DRD2DRD4DRD3ALDH1A1LMNA | |
| SCHEMBL24450334 | 0.85 | HTT (0.73) | DRD2DRD4DRD3ALDH1A1LMNA | |
| SCHEMBL12209849 | 0.83 | ALDH1A1 (0.60) | DRD2ALDH1A1LMNAKMT2AGAA | |
| SCHEMBL3165125 | 0.80 | ALDH1A1 (0.57) | DRD2ALDH1A1LMNAKMT2AGAA | |
| SCHEMBL24652524 | 0.80 | ALDH1A1 (0.57) | DRD2ALDH1A1LMNAKMT2AGAA | |
| SCHEMBL15549867 | 0.75 | SLC18A3 (0.62) | DRD2DRD4DRD3ALDH1A1LMNA | |
| SCHEMBL26238905 | 0.75 | PRCP (0.58) | DRD2DRD4DRD3HTTSLC18A3 | |
| SCHEMBL4613768 | 0.75 | HSD11B1 (0.62) | ALDH1A1LMNAHTTNPC1RAB9A | |
| SCHEMBL26986820 | 0.75 | SLC18A3 (0.58) | DRD2DRD4DRD3HTTCARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252644-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. (US) | 2021-12-16 | — | — | WO | disclosed |