Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.94 |
| ▸ | HMGCR | P04035 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL116215 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL2593972 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL11519286 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL2411531 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1426398 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL633793 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL7060057 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL11857836 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL8400312 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4819877 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 557513 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118830618-A | Anthocyanin-containing composition and application thereof in preparation of product with effect of improving insulin resistance | 广东君道营养科技有限公司 | 2024-10-25 | — | — | CN | claimed |
| CN-116851010-B | Binary, ternary and/or multi-element metal selenide with multi-class enzyme catalytic activity, and preparation method and application thereof | 华南农业大学 | 2024-09-24 | — | — | CN | claimed |
| CN-118680854-A | A cream containing plant extract for promoting hair whitening and blackening, and its preparation method | 广州卡蒂丝生物科技有限公司 | 2024-09-24 | — | — | CN | claimed |
| CN-118390287-B | Self-supporting polyanion positive electrode material, preparation method thereof, positive electrode plate and battery | 江苏中兴派能电池有限公司 | 2024-09-24 | — | — | CN | claimed |
| CN-118681552-A | (CaMn) SiOx (x=4-6) material, preparation method thereof and application thereof in ozone catalytic water purification process | 浙江工业大学 | 2024-09-24 | — | — | CN | claimed |
| WO-2024189661-A1 | A TOPICAL COMPOSITION COMPRISING A TERNARY METAL OXIDE NANOPARTICLE PRESERVATIVE | JORDAN UNIVERSITY OF SCIENCE AND TECHNOLOGY (JO) | 2024-09-19 | — | — | WO | claimed |
| CN-116102319-B | Composite fiber reinforced concrete and preparation method thereof | 湖南城市学院 | 2024-09-17 | — | — | CN | claimed |
| CN-116283043-B | Ultra-early-strength admixture for UHPC prefabricated part and preparation method thereof | 中交二航武汉港湾新材料有限公司 | 2024-09-13 | — | — | CN | claimed |
| CN-118635500-A | Preparation method of nano silver particles with controllable granularity | 宁波维柔电子科技有限公司 | 2024-09-13 | — | — | CN | claimed |
| WO-2024187137-A2 | COMBINATION THERAPY OF ANTI-PD-1 ACTIVE AGENT, ANTI-TIM-3 ACTIVE AGENT, AND ANTI-LAG-3 ACTIVE AGENT FOR TREATING CANCER | INCYTE CORPORATION (US) | 2024-09-12 | — | — | WO | claimed |
| US-3947570-A | MOUTHWASH, LEMON OIL | COLGATE-PALMOLIVE COMPANY (US) | 1976-03-30 | — | — | US | claimed |
| US-3945951-A | ANTIOXIDANTS, SULFIDES, OXY, CARBO | KAO SOAP CO., LTD. (JA) | 1976-03-23 | — | — | US | claimed |
| US-3941723-A | Crystallized alkali metal silicate with sequestering agents | PHILADELPHIA QUARTZ COMPANY (US) | 1976-03-02 | — | — | US | claimed |
| US-3937282-A | Method for cementing wells in low temperature formations | HALLIBURTON COMPANY (US) | 1976-02-10 | — | — | US | claimed |
| US-3936434-A | Cytobiotic globulins for kidney treatment | OMNIUM FINANCIER AQUITAINE POUR L'HYGIENE ET LA SANTE (SANOFI) (FR) | 1976-02-03 | — | — | US | claimed |
| US-3935323-A | CHEESE WHEY | STAUFFER CHEMICAL COMPANY (US) | 1976-01-27 | — | — | US | claimed |
| US-3932618-A | REACTION PRODUCT OF BLOOD AND A PROTEASE | OTSUKA KAGAKU YAKUHIN KABUSHIKI KAISHA (JA) | 1976-01-13 | — | — | US | claimed |
| US-3932680-A | STABILIZERS | ZENTRALSCHWEIZERISCHER MILCHVERBAND (CH) | 1976-01-13 | — | — | US | claimed |
| US-3932655-A | CHELATING AGENTS, N-ALKYL BENZALKONIUM CHLORIDES | INTERNATIONAL PHARMAKON LABORATORIES, INC. (US) | 1976-01-13 | — | — | US | claimed |
| US-3930896-A | NICKEL-COBALT ALLOY | TATSUTA DENSEN KABUSHIKI KAISHA (JA) | 1976-01-06 | — | — | US | claimed |