Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | ATF4 | P18848 | 4/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24116617 | 0.90 | GRIN1 (0.40) | GRIN1GRIN2BATF4GFERALDH1A1 | |
| SCHEMBL24116584 | 0.88 | ALDH1A1 (0.41) | GRIN1GRIN2BATF4GFERALDH1A1 | |
| SCHEMBL22627974 | 0.85 | TDP1 (0.51) | ATF4ALDH1A1 | |
| SCHEMBL24116604 | 0.84 | GRIN1 (0.39) | GRIN1GRIN2BATF4ALDH1A1SYK | |
| SCHEMBL24116615 | 0.84 | ATF4 (0.43) | ATF4ALDH1A1HDAC8HDAC1HDAC3 | |
| SCHEMBL25960311 | 0.83 | SYK (0.38) | ATF4GFERALDH1A1SYKFFAR4 | |
| SCHEMBL25796793 | 0.83 | TDP1 (0.53) | ATF4 | |
| SCHEMBL22627559 | 0.78 | ATF4 (0.41) | ATF4ALDH1A1 | |
| SCHEMBL22627948 | 0.78 | MEN1 (0.46) | ATF4ALDH1A1FFAR4 | |
| SCHEMBL23455838 | 0.77 | ATF4 (0.52) | ATF4SMN1; SMN2KDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210393599-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2021-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210393599-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | GRIN1 1690/4885GRIN2B 2324/4885ATF4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.