Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.43 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.41 |
| ▸ | GCG | P01275 | 3/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24117971 | 0.87 | KDM4E (0.48) | CXCR1CXCR2P4HTMMEN1KMT2A | |
| SCHEMBL24117943 | 0.85 | EPHX2 (0.43) | EPHX2KCNH2 | |
| SCHEMBL24118075 | 0.83 | USP36 (0.45) | EPHX2 | |
| SCHEMBL24118250 | 0.81 | ALDH1A1 (0.54) | EPHX2MEN1KMT2APOLB | |
| SCHEMBL24118632 | 0.80 | GCGR (0.48) | — | |
| SCHEMBL24118272 | 0.80 | MEN1 (0.44) | CYP2C9CYP2C19GCGIDO1MEN1 | |
| SCHEMBL24117949 | 0.79 | IDO1 (0.53) | GCGIDO1MEN1KMT2APOLB | |
| SCHEMBL24118386 | 0.78 | MEN1 (0.42) | CYP2C9CYP2C19GCGIDO1MEN1 | |
| SCHEMBL24118073 | 0.78 | ALDH1A1 (0.46) | CYP2C9CYP2C19GCGIDO1MEN1 | |
| SCHEMBL24118311 | 0.78 | ALDH1A1 (0.46) | CYP2C9CYP2C19GCGIDO1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210393600-A1 | Novel [1.1.1] Bicyclo Compounds as Indoleamine 2,3-Dioxygenase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210393600-A1 | Novel [1.1.1] Bicyclo Compounds as Indoleamine 2,3-Dioxygenase Inhibitors | IDO1, IDO2, TPH1 | EPHX2 805/4885CYP2C9 909/4885CYP2C19 928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.