Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CXCR1 | P25024 | 6/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 6/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24118232 | 0.87 | EPHX2 (0.43) | CXCR1CXCR2P4HTMKMT2AMEN1 | |
| SCHEMBL24118115 | 0.82 | SCN10A (0.43) | KDM4EALDH1A1GAASMN1; SMN2KMT2A | |
| SCHEMBL24118272 | 0.82 | MEN1 (0.44) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL24118244 | 0.82 | ALDH1A1 (0.51) | KDM4EKCNQ3KCNQ2ALDH1A1SMN1; SMN2 | |
| SCHEMBL24118073 | 0.82 | ALDH1A1 (0.46) | ALDH1A1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL24118311 | 0.82 | ALDH1A1 (0.46) | ALDH1A1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL24117949 | 0.82 | IDO1 (0.53) | KDM4EKCNQ3KCNQ2ALDH1A1KMT2A | |
| SCHEMBL24118386 | 0.81 | MEN1 (0.42) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL24118612 | 0.80 | L3MBTL1 (0.40) | KDM4EALDH1A1NPC1GAARAB9A | |
| SCHEMBL24117930 | 0.80 | CYP1A2 (0.49) | KDM4EALDH1A1NPC1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210393600-A1 | Novel [1.1.1] Bicyclo Compounds as Indoleamine 2,3-Dioxygenase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210393600-A1 | Novel [1.1.1] Bicyclo Compounds as Indoleamine 2,3-Dioxygenase Inhibitors | IDO1, IDO2, TPH1 | KDM4E 1721/4885KCNQ3 4341/4885KCNQ2 4068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.