Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.47 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.47 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | RHOC | P08134 | 2/20 | 0.47 |
| ▸ | RHOA | P61586 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24117941 | 0.87 | POLB (0.51) | ALDH1A1POLBTP53MEN1KMT2A | |
| SCHEMBL24117953 | 0.85 | RHOC (0.50) | ALDH1A1POLBTP53MEN1KMT2A | |
| SCHEMBL24117910 | 0.83 | RHOC (0.45) | ALDH1A1POLBTP53MEN1KMT2A | |
| SCHEMBL24118257 | 0.81 | KCNQ3 (0.54) | ALDH1A1KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL24118071 | 0.78 | POLB (0.54) | ALDH1A1POLBMEN1KMT2ARHOC | |
| SCHEMBL24118064 | 0.73 | IDO1 (0.46) | ALDH1A1POLBKCNQ3KCNQ2KCNE1 | |
| SCHEMBL24117930 | 0.72 | CYP1A2 (0.49) | ALDH1A1POLBTP53MEN1KMT2A | |
| SCHEMBL19835598 | 0.72 | HPGD (0.73) | ALDH1A1POLBKCNQ3KCNQ2KCNE1 | |
| SCHEMBL6361467 | 0.71 | KMT2A (0.61) | ALDH1A1POLBKCNQ3KCNQ2KCNE1 | |
| SCHEMBL24117949 | 0.71 | IDO1 (0.53) | ALDH1A1POLBKCNQ3KCNQ2KCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210393600-A1 | Novel [1.1.1] Bicyclo Compounds as Indoleamine 2,3-Dioxygenase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210393600-A1 | Novel [1.1.1] Bicyclo Compounds as Indoleamine 2,3-Dioxygenase Inhibitors | IDO1, IDO2, TPH1 | ALDH1A1 144/4885POLB 1950/4885KCNQ3 4341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.