Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | RHOC | P08134 | 3/20 | 0.53 |
| ▸ | RHOA | P61586 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.47 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24118250 | 0.82 | ALDH1A1 (0.54) | POLBALDH1A1RHOCRHOAHDAC3 | |
| SCHEMBL30739967 | 0.79 | LMNA (0.78) | POLBRHOCRHOAPTGS1LMNA | |
| SCHEMBL24118320 | 0.78 | ALDH1A1 (0.50) | POLBALDH1A1RHOCRHOAMEN1 | |
| SCHEMBL24117953 | 0.77 | RHOC (0.50) | POLBALDH1A1RHOCRHOAHDAC3 | |
| SCHEMBL24117941 | 0.77 | POLB (0.51) | POLBALDH1A1RHOCRHOALMNA | |
| SCHEMBL24117910 | 0.74 | RHOC (0.45) | POLBALDH1A1RHOCRHOAMEN1 | |
| SCHEMBL24118257 | 0.73 | KCNQ3 (0.54) | ALDH1A1LMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL3514277 | 0.72 | POLB (0.76) | POLBALDH1A1HDAC3HDAC1LMNA | |
| SCHEMBL3514281 | 0.72 | POLB (0.76) | POLBALDH1A1HDAC3HDAC1LMNA | |
| SCHEMBL13806887 | 0.71 | DDR1 (0.59) | POLBALDH1A1HDAC3HDAC1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210393600-A1 | Novel [1.1.1] Bicyclo Compounds as Indoleamine 2,3-Dioxygenase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210393600-A1 | Novel [1.1.1] Bicyclo Compounds as Indoleamine 2,3-Dioxygenase Inhibitors | IDO1, IDO2, TPH1 | POLB 1950/4885ALDH1A1 144/4885RHOC 3918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.