Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26196832 | 0.87 | MAOB (0.40) | MAOAMAOBTEAD3HDAC3HDAC4 | |
| SCHEMBL23043142 | 0.85 | SMN1; SMN2 (0.43) | MAOAMAOBTEAD3TSHRHDAC3 | |
| SCHEMBL26196844 | 0.84 | TEAD3 (0.41) | LTA4HMAOAMAOBTEAD3TSHR | |
| SCHEMBL23053810 | 0.79 | ALDH1A1 (0.46) | LTA4HMCL1TSHRKDM4ECTSL | |
| SCHEMBL26046366 | 0.77 | LTA4H (0.40) | LTA4HMAOAMAOBMAPTMCL1 | |
| SCHEMBL26196843 | 0.77 | TDP1 (0.43) | LTA4HMAOAMAOBMAPTMCL1 | |
| SCHEMBL23043559 | 0.77 | LTA4H (0.40) | LTA4HTEAD3MAPTMCL1TSHR | |
| SCHEMBL24127752 | 0.76 | SMN1; SMN2 (0.49) | LTA4HMAPTTSHRTDP1 | |
| SCHEMBL27673042 | 0.75 | MCL1 (0.39) | LTA4HMAOAMAOBMAPTMCL1 | |
| SCHEMBL23043763 | 0.74 | LTA4H (0.40) | LTA4HMAOAMAOBTEAD3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021257828-A1 | SUBSTITUTED THIENOPYRIMIDINES THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY THERAPEUTICS, LLC (US) | 2021-12-23 | — | — | WO | disclosed |