Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.31 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | NAAA | Q02083 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22434644 | 0.84 | CYP19A1 (0.36) | SLC6A3KDM4EALDH1A1IMPDH2IMPDH1 | |
| SCHEMBL20504978 | 0.73 | TSHR (0.37) | ALDH1A1 | |
| SCHEMBL20505334 | 0.71 | CD274 (0.32) | — | |
| SCHEMBL28476656 | 0.71 | GLA (0.32) | KDM4ENPSR1 | |
| SCHEMBL24136167 | 0.71 | IMPDH2 (0.37) | SLC6A3KDM4EALDH1A1IMPDH2IMPDH1 | |
| SCHEMBL22434674 | 0.67 | CYP19A1 (0.42) | KDM4EALDH1A1 | |
| SCHEMBL3649084 | 0.65 | MAPT (0.40) | KDM4EALDH1A1IMPDH2IMPDH1USP2 | |
| SCHEMBL186647 | 0.65 | MAPT (0.43) | KDM4EALDH1A1IMPDH2IMPDH1USP2 | |
| SCHEMBL3447232 | 0.65 | CA2 (0.41) | KDM4EALDH1A1NPSR1 | |
| SCHEMBL20505467 | 0.64 | KDM4E (0.37) | SLC6A3KDM4EALDH1A1IMPDH2IMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3928836-A1 | N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2021-12-29 | — | — | EP | disclosed |