Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NQO1 | P15559 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.31 |
| ▸ | AR | P10275 | 3/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22434808 | 0.84 | IMPDH2 (0.38) | IMPDH2IMPDH1KDM4EUSP2ALDH1A1 | |
| SCHEMBL24136189 | 0.78 | MEN1 (0.35) | KDM4EALDH1A1MEN1KMT2ANQO1 | |
| SCHEMBL24136204 | 0.77 | L3MBTL1 (0.35) | ALDH1A1MEN1KMT2ANQO1LMNA | |
| SCHEMBL24136211 | 0.73 | IMPDH2 (0.39) | IMPDH2IMPDH1KDM4EALDH1A1MEN1 | |
| SCHEMBL20505499 | 0.71 | KMT2A (0.34) | KMT2ALMNAMAPK1HTTRAB9A | |
| SCHEMBL28479024 | 0.71 | KMT2A (0.32) | KDM4EALDH1A1KMT2ALMNAMAPK1 | |
| SCHEMBL24136165 | 0.71 | SLC6A3 (0.32) | IMPDH2IMPDH1KDM4EUSP2ALDH1A1 | |
| SCHEMBL22434645 | 0.69 | PGR (0.34) | AR | |
| SCHEMBL22434669 | 0.67 | CYP19A1 (0.40) | KDM4EALDH1A1MEN1KMT2ANQO1 | |
| SCHEMBL24136181 | 0.67 | AR (0.30) | KDM4EALDH1A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3928836-A1 | N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2021-12-29 | — | — | EP | disclosed |